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Skin sensitization in silico protocol

Johnson, C, Ahlberg, E, Anger, LT, Beilke, L, Benigni, R, Bercu, J, Bobst, S, Bower, D, Brigo, A, Campbell, S, Cronin, MTD, Crooks, I, Cross, CP, Doktorova, T, Exner, T, Faulkner, D, Fearon, IM, Fehr, M, Gad, SC, Gervais, V , Giddings, A, Glowienke, S, Hardy, B, Hasselgren, C, Hillegass, J, Jolly, R, Krupp, E, Lomnitski, L, Magby, J, Mestres, J, Milchak, L, Miller, S, Muster, W, Neilson, L, Parakhia, R, Parenty, A, Parris, P, Paulino, A, Paulino, AT, Roberts, DW, Schlecker, H, Stidl, R, Suarez-Rodrigez, D, Szabo, DT, Tice, RR, Urbisch, D, Vuorinen, A, Wall, B, Weiler, T, White, AT, Whritenour, J, Wichard, J, Woolley, D, Zwickl, C and Myatt, GJ (2020) Skin sensitization in silico protocol. Regulatory Toxicology and Pharmacology. ISSN 0273-2300

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Abstract

The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the strengths of in silico methods to support a weight of evidence assessment without conducting a test in animals. While in silico methods vary greatly in their purpose and format; there is a need to standardize the underlying principles on which such models are developed and to make transparent the implications for the uncertainty in the overall assessment. In this contribution, the relationship of skin sensitization relevant effects, mechanisms, and endpoints are built into a hazard assessment framework. Based on the relevance of the mechanisms and effects as well as the strengths and limitations of the experimental systems used to identify them, rules and principles are defined for deriving skin sensitization in silico assessments. Further, the assignments of reliability and confidence scores that reflect the overall strength of the assessment are discussed. This skin sensitization protocol supports the implementation and acceptance of in silico approaches for the prediction of skin sensitization.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RL Dermatology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 02 Jul 2020 10:05
Last Modified: 02 Jul 2020 10:15
DOI or Identification number: 10.1016/j.yrtph.2020.104688
URI: http://researchonline.ljmu.ac.uk/id/eprint/13223

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