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Olajide, OA and Sarker, SD (2020) Alzheimer’s disease: Natural products as inhibitors of neuroinflammation. Inflammopharmacology, 28. pp. 1439-1455. ISSN 0925-4692
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Abstract
Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1115 Pharmacology and Pharmaceutical Sciences |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Springer Verlag |
| Date Deposited: | 26 Aug 2020 14:55 |
| Last Modified: | 11 Jan 2022 16:30 |
| DOI or ID number: | 10.1007/s10787-020-00751-1 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/13552 |
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