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Alzheimer’s disease: Natural products as inhibitors of neuroinflammation

Olajide, OA and Sarker, SD Alzheimer’s disease: Natural products as inhibitors of neuroinflammation. Inflammopharmacology. ISSN 0925-4692 (Accepted)

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer Verlag
Date Deposited: 26 Aug 2020 14:55
Last Modified: 26 Aug 2020 15:00
URI: http://researchonline.ljmu.ac.uk/id/eprint/13552

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