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C-Low Threshold Mechanoafferent Targeted Dynamic Touch Modulates Stress Resilience in Rats Exposed to Chronic Mild Stress.

Walker, SC, Cavieres, A, Peñaloza-Sancho, V, El-Deredy, W, McGlone, FP and Dagnino-Subiabre, A (2020) C-Low Threshold Mechanoafferent Targeted Dynamic Touch Modulates Stress Resilience in Rats Exposed to Chronic Mild Stress. European Journal of Neuroscience. ISSN 1460-9568

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Abstract

Affiliative tactile interactions buffer social mammals against neurobiological and behavioral effects of stress. The aim of the present study was to investigate the cutaneous mechanisms underlying such beneficial consequences of touch by determining whether daily stroking, specifically targeted to activate a velocity/force tuned class of low-threshold c-fiber mechanoreceptor (CLTM), confers resilience against established markers of chronic unpredictable mild stress (CMS). Adult male Sprague Dawley rats were exposed to two weeks of CMS. Throughout the CMS protocol, some rats were stroked daily, either at CLTM optimal velocity (5cm/s) or outside the CLTM optimal range (30cm/s). A third CMS exposed group did not receive any tactile stimulation. The effect of CMS on serum corticosterone levels, anxiety- and depressive-like behaviors in these three groups was assessed in comparison to a control group of non-CMS exposed rats. While stroking did not mitigate the effects of CMS on body weight gain, CLTM optimal velocity stroking did significantly reduce CMS induced elevations in corticosterone following an acute forced-swim. Rats receiving CLTM optimal stroking also showed significantly fewer anxiety-like behaviors (elevated plus-maze) than the other CMS exposed rats. In terms of depressive-like behavior, while the same velocity specific resilience was observed in a forced-swim test (FST) and social interaction test both groups of stroked rats spent significantly less time interacting than control rats, though they also spent significantly less time in the corner than non-stroked CMS rats. Together, these findings support the theory CLTMs play a functional role in regulating the physiological condition of the body.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Walker, SC, Cavieres, A, Peñaloza‐Sancho, V, El‐Deredy, W, McGlone, FP, Dagnino‐Subiabre, A. C‐low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress. Eur J Neurosci. 2020; 00: 1– 14. https://doi.org/10.1111/ejn.14951, which has been published in final form at https://dx.doi.org/10.1111/ejn.14951. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords: 1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (new Sep 2019)
Publisher: Wiley
Related URLs:
Date Deposited: 09 Oct 2020 11:27
Last Modified: 09 Oct 2020 11:27
DOI or Identification number: 10.1111/ejn.14951
URI: https://researchonline.ljmu.ac.uk/id/eprint/13568

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