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The Acute and Chronic Effects of High-Intensity Exercise in Hypoxia on Blood Pressure and Post-Exercise Hypotension: a randomized cross-over trial

Kleinnibbelink, G, Stens, N, Fornasiero, A, Speretta, G, van Dijk, A, Low, DA, Oxborough, D and Thijssen, DHJ The Acute and Chronic Effects of High-Intensity Exercise in Hypoxia on Blood Pressure and Post-Exercise Hypotension: a randomized cross-over trial. Medicine. ISSN 0025-7974 (Accepted)

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Abstract

Background and objectives. Acute exercise leads to an immediate drop in blood pressure (BP), also called post-exercise hypotension (PEH). Exercise in hypoxia is related to additional vasodilation, potentially contributing to more profound PEH. Therefore, we investigated the impact of hypoxia versus normoxia on the magnitude of PEH. Secondly, we examined whether these changes in PEH relate to the BP-lowering effects of 12-week exercise training under hypoxia.
Methods. In this prospective study, twenty-one healthy individuals (age 22.2±3.0 years, fourteen male) performed a 45-minute high-intensity running exercise on two different days in a random order, under hypoxia (fraction of inspired oxygen (FiO2) 14.5%) and normoxia (FiO2 20.9%). BP was examined pre-exercise (t=0) and at t=15, t=30, t=45 and t=60min post-exercise. Afterwards, subjects took part in a 12-week hypoxic running exercise training program. Resting BP was measured before and after the 12-week training program.
Results. Acute exercise induced a significant decrease in systolic BP (SBP, P=0.001), but not in diastolic BP (DBP, P=0.113). No significant differences were observed in post-exercise BP between hypoxic and normoxic conditions (SBP, P=0.324 and DBP, P=0.204). Post-exercise changes in SBP, DBP and MAP significantly correlated to the 12-week exercise training induced changes in SBP (r=0.557, P=0.001), DBP (r=0.615, P<0.001), and MAP (r=0.458, P=0.011).
Conclusion. Our findings show that hypoxia does not alter the magnitude of PEH in healthy individuals, whilst PEH relates to the BP-lowering effects of exercise. These data highlight the strong link between acute and chronic changes in BP.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins
Date Deposited: 10 Sep 2020 09:33
Last Modified: 10 Sep 2020 09:33
URI: https://researchonline.ljmu.ac.uk/id/eprint/13615

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