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Effects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.

Darand, M, Farrokhzad, A, Ghavami, A, Hadi, A, Karimi, E, Fadel, A and Askari, G (2020) Effects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. International Journal of Clinical Practice. ISSN 1368-5031

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Abstract

BACKGROUND: The available evidence regarding the possible effects of resveratrol on liver function is inconsistent. Therefore, the present meta-analysis was performed to investigate the overall effects of resveratrol supplementation on liver enzymes in adults. METHODS: A systematic and comprehensive search of the online medical databases including PubMed, Scupos, Web of Science and Cochran Library was performed up to February 2020. All RCTs using resveratrol supplements in adults were included in this systematic review and meta-analysis. The overall effect was presented as weighted mean difference (WMD) and 95% confidence interval (CI) in a random-effects meta-analysis model. RESULTS: Finally, 15 randomized trials including 714 participants were selected for the present meta-analysis. Pooled analysis did not show any significant changes in alanine aminotransferase (ALT) (WMD: 0 IU/L, 95% CI: -3.17 to 3.17, p = 0.99; I2 = 74.2%), aspartate aminotransferase (AST) (WMD: -2.40 IU/L, 95% CI: -5.45 to 0.65, p = 0.11; I2 = 82.9%), gamma-glutamyl transferase (GGT) (WMD: -1.26 IU/L, 95% CI: -4.64 to 2.13, p = 0.64; I2 = 23.7%), alkaline phosphatase (ALP) (WMD: 3.80 IU/L, 95% CI: -4.65 to 12.25, p = 0.37; I2 = 29.9%) and bilirubin (WMD: 0.13 IU/L, 95% CI: -0.43 to 0.17, p = 0.39; I2 = 8.9%) after supplementation with resveratrol. CONCLUSION: Overall in our study resveratrol does not effect on liver enzyme levels significantly, but subgroup analysis indicates that these results may be influenced by resveratrol dose, duration of the study and population status, so future high-quality studies are necessary to get definitive results.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Darand, M., Farrokhzad, A., Ghavami, A., Hadi, A., Karimi, E., Fadel, A. and Askari, G. (2020), Effects of resveratrol supplementation on liver enzymes: A systematic review and meta‐analysis of randomized controlled trials. Int J Clin Pract. Accepted Author Manuscript. doi:10.1111/ijcp.13692, which has been published in final form at https://dx.doi.org/10.1111/ijcp.13692. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
Uncontrolled Keywords: 1103 Clinical Sciences, 1117 Public Health and Health Services, 1701 Psychology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 11 Sep 2020 12:08
Last Modified: 11 Sep 2020 12:15
DOI or Identification number: 10.1111/ijcp.13692
URI: https://researchonline.ljmu.ac.uk/id/eprint/13635

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