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Penson, P, Pirro, M and Banach, M (2020) LDL-C: Lower is Better for Longer - Even at Low Risk. BMC Medicine, 18. ISSN 1741-7015
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LDL-C lower is better for longer—even at low risk.pdf - Published Version Available under License Creative Commons Attribution. Download (823kB) | Preview |
Abstract
Background: Low-density lipoprotein cholesterol (LDL-C) causes atherosclerotic disease, as demonstrated in experimental and epidemiological cohorts, randomised controlled trials, and Mendelian randomisation studies.
Main text: There is considerable inconsistency between existing guidelines as to how to effectively manage patients at low overall risk of cardiovascular disease (CVD) who have persistently elevated levels of LDL-C.
We propose a step-by-step practical approach for the management of cardiovascular risks in individuals with low (< 1%) 10-year risk of CVD, and elevated (> 140 mg/dL, 3.6 mmol/L) LDL-C. The strategy proposed is based on the level of adherence to lifestyle interventions (LSI), and in case of non-adherence, stepwise practical management, including lipid-lowering therapy, is recommended to achieve a target LDL-C levels (< 115 mg/dL, 3.0 mmol/L).
Conclusions: Further studies are necessary to answer the questions on the long-term efficacy, safety, and cost-effectiveness of the suggested approach. This is critical, considering the ever-increasing numbers of such low-risk patients seen in clinical practice.
| Item Type: | Article |
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| Uncontrolled Keywords: | 11 Medical and Health Sciences |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | BioMed Central |
| Date Deposited: | 12 Oct 2020 11:14 |
| Last Modified: | 04 Sep 2021 06:32 |
| DOI or ID number: | 10.1186/s12916-020-01792-7 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/13823 |
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