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Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions

Ruiz, AJ, Tibary, A, Heaton, R, Hargreaves, IP, Leadon, DP and Bayly, WM Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions. Journal of Equine Veterinary Science. ISSN 0737-0806 (Accepted)

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Abstract

Although coenzyme Q10 (CoQ10) serves as an antioxidant and energy source for spermatozoa when added to stallion semen prior to cooling or freezing, the effects of feeding CoQ10 on semen quality have not been studied. We assessed the effects of daily oral ingestion of CoQ10-ubiquinol by stallions on their plasma CoQ10 concentrations and semen quality.
Seven mature Andalusian stallions ate 1g ubiquinol/day for 4 weeks followed by a 4-week wash-out period. Four horses initially completed an additional 4-week control period without ubiquinol. Blood was sampled weekly for determination of plasma CoQ10 concentrations. Ejaculates were collected every two weeks and assessed for total motility (TM), progressive motility (PM) and viability (V) after cooling for 24h (T1), immediate cryopreservation (T2), and cryopreservation following 24h cooling (T3). Ingesting ubiquinol resulted in an increase in plasma CoQ10 concentration (p < .001). Two weeks of CoQ10-ubiquinol resulted in improved V with all treatments (T1: p=.007; T2: p=.05; T3: p=.01) and PM with T3 (p=.04). In five stallions, TM and PM were also improved for T1 (p=.01 and p=.02, respectively) and TM increased with T2 (p=.03). Overall, semen quality parameters increased within the first 2 weeks of supplementation, plateaxued at the end of the 4-week supplementation period and persisted after discontinuing ubiquinol until the end of the sampling period (8 weeks).
Feeding 1g CoQ10-ubiquinol for 4 weeks to breeding stallions improved semen quality after cooling and freezing in 5 of 7 stallions. This could be important for improving reproductive efficiency in stallions.

Item Type: Article
Uncontrolled Keywords: 0707 Veterinary Sciences
Subjects: Q Science > QL Zoology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 20 Oct 2020 11:20
Last Modified: 20 Oct 2020 11:30
DOI or Identification number: 10.1016/j.jevs.2020.103303
URI: https://researchonline.ljmu.ac.uk/id/eprint/13861

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