Serial position effects in the Logical Memory Test: Loss of primacy predicts amyloid positivity

Bruno, D, Mueller, K, Betthauser, T, Chin, N, Engelman, C, Christian, B, Koscik, R and Johnson, S (2020) Serial position effects in the Logical Memory Test: Loss of primacy predicts amyloid positivity. Journal of Neuropsychology, 15 (3). pp. 448-461. ISSN 1748-6645

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Abstract

Background
Story recall is a frequently used neuropsychological test of episodic memory with clinical populations and for screening participants in drug trials for Alzheimer’s disease. However, it is unclear at this stage which underlying mechanisms confer the test its sensitivity. In this paper, we examined serial position effects, that is, better recall for items learned early and late on a list, in story recall, and their usefulness to predict early changes associated with neurodegenerative markers.

Methods
We analysed data from the Wisconsin Registry for Alzheimer’s Prevention. First, we tested whether serial position effects were present in story recall (measured with the Wechsler Memory Scale Logical Memory Task; LMT) across individuals who were classified as cognitively unimpaired – stable, cognitively unimpaired – declining, or as having mild cognitive impairment (MCI).

Results
Our results showed clear serial position effects for all groups, except for delayed recall among individuals with MCI, where no primacy effect was observed. Second, we tested whether loss of primacy from immediate to delayed recall was associated with amyloid burden (as measured with PiB PET) in individuals who were cognitively unimpaired at baseline. We found that more primacy loss predicted amyloid positivity, above and beyond the LMT total score.

Conclusions
This report is the first to show that loss of primacy between immediate and delayed story recall is associated with amyloid burden.

Item Type:	Article
Additional Information:	This is the peer reviewed version of the following article: Bruno, D., Mueller, K.D., Betthauser, T., Chin, N., Engelman, C.D., Christian, B., Koscik, R.L. and Johnson, S.C. (2021), Serial position effects in the Logical Memory Test: Loss of primacy predicts amyloid positivity. J Neuropsychol, 15: 448-461 which has been published in final form at https://doi.org/10.1111/jnp.12235. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords:	11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Psychology (from Sep 2019)
Publisher:	Wiley
Date of acceptance:	16 November 2020
Date of first compliant Open Access:	11 January 2022
Date Deposited:	18 Nov 2020 11:05
Last Modified:	11 Jan 2022 13:15
DOI or ID number:	10.1111/jnp.12235
URI:	https://researchonline.ljmu.ac.uk/id/eprint/14029

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