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Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology

Huang, R, Shen, Y-W, Guan, Y-Y, Jiang, Y-X, Wu, Y, Rahman, K, Zhang, L-J, Liu, H-J and Luan, X (2020) Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology. Acta Biomaterialia, 116. pp. 1-15. ISSN 1742-7061

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Abstract

Mesoporous silica nanoparticles (MSNs) have received increasing interest due to their tunable particle size, large surface area, stable framework, and easy surface modification. They are increasingly being used in varying applications as delivery vehicles including bio-imaging, drug delivery, biosensors and tissue engineering etc. Precise structure control and the ability to modify surface properties of MSNs are important for their applications. This review summarises the different synthetic methods for the preparation of well-ordered MSNs with tunable pore volume as well as the approaches of drugs loading, especially highlighting the facile surface functionalization for various purposes and versatile biomedical applications in oncology. Finally, the challenges of clinical transformation of MSNs-based nanomedicines are further discussed.

Keywords: Mesoporous silica nanoparticles; synthesis method; surface functionalization; drug delivery; biomedical application.

Item Type: Article
Uncontrolled Keywords: Science & Technology; Technology; Engineering, Biomedical; Materials Science, Biomaterials; Engineering; Materials Science; Mesoporous silica nanoparticles; Synthesis method; Surface functionalization; Drug delivery; Biomedical application; WELL-ORDERED MESOSTRUCTURE; DRUG-DELIVERY; ORGANOSILICA NANOPARTICLES; BREAST-CANCER; INTRACELLULAR RELEASE; PHOTOTHERMAL THERAPY; GOLD NANOPARTICLES; ASSISTED SYNTHESIS; MOLECULAR-SIEVE; PARTICLE-SIZE
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Related URLs:
Date Deposited: 27 Nov 2020 12:55
Last Modified: 27 Nov 2020 12:55
DOI or Identification number: 10.1016/j.actbio.2020.09.009
URI: https://researchonline.ljmu.ac.uk/id/eprint/14078

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