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Relation between physical activity and cerebral small vessel disease: A nine-year prospective cohort study.

Landman, TR, Thijssen, DHJ, Tuladhar, AM and de Leeuw, F-E (2021) Relation between physical activity and cerebral small vessel disease: A nine-year prospective cohort study. International Journal of Stroke. ISSN 1747-4930

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Abstract

BACKGROUND AND AIMS: Given the unexplored potential of physical activity to reduce the progression of cerebral small vessel disease (cSVD, the purpose of this study was to prospectively (across nine-year follow-up) examine the relation between (baseline) physical activity and the (clinical and imaging) consequences of the whole spectrum of cerebral small vessel disease. METHODS: Five hundred and three patients with cerebral small vessel disease from the RUNDMC study were followed for nine years. Physical activity was assessed using a questionnaire in 2006, 2011, and 2015. Clinical events (i.e. all-cause mortality, cerebrovascular events (by stroke subtype)) were collected with a structured questionnaire. Patients underwent magnetic resonance imaging scanning for the assessment of magnetic resonance imaging markers of cerebral small vessel disease (i.e. white matter hyperintensities, lacunes, and microbleeds) and microstructural integrity of the white matter at three timepoints. RESULTS: The mean age at baseline was 66 (SD 9.0) years; 44% were women. A higher baseline physical activity level was independently associated with a lower all-cause mortality (HR: 0.69, 95%CI: 0.49-0.98, p = 0.03) and incidence of cerebrovascular disease (HR: 0.58, 95%CI: 0.36-0.96, p = 0.03). However, we found no relation between physical activity and incident lacunar stroke or progression of magnetic resonance imaging markers of cerebral small vessel disease. CONCLUSIONS: Whilst regular physical activity was not related to the progression of magnetic resonance imaging markers of cerebral small vessel disease across a nine-year follow-up, results from our study prove that high levels of physical activity in patients with cerebral small vessel disease are associated with a lower all-cause mortality and lower incidence of cerebrovascular events.

Item Type: Article
Additional Information: Landman, TR., Thijssen, DHJ., Tuladhar, AM. & de Leeuw, FE. Relation between physical activity and cerebral small vessel disease: A nine-year prospective cohort study. International Journal of Stroke. Copyright © 2020 (Sage). https://dx.doi.org/10.1177/1747493020984090
Uncontrolled Keywords: 1103 Clinical Sciences, 1109 Neurosciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Sage
Related URLs:
Date Deposited: 18 Jan 2021 13:42
Last Modified: 18 Jan 2021 13:45
DOI or Identification number: 10.1177/1747493020984090
URI: https://researchonline.ljmu.ac.uk/id/eprint/14286

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