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The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males.

Chan, KQ, Stewart, CE, Chester, N, Hamzah, SH and Yusof, A (2021) The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males. Andrologia. ISSN 0303-4569

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Abstract

Eurycoma longifolia supplementation increases testosterone levels in humans via activation of the hypothalamic-pituitary-gonadal axis and/or the hypothalamic-pituitary-adrenal axis mainly in older adults and nonhealthy populations. This study aimed to assess the impact of Eurycoma longifolia on the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in healthy young males since this might promote functional testosterone prowess. Thirty-two males (24.4 ± 4.7 years; 1.74 ± 0.07 m; 73.7 ± 8.4 kg) in a placebo-controlled, double-blind, matched-paired study received 600 mg/day Eurycoma longifolia or placebo for two weeks. Blood analysis using repeated measures analysis of variance showed significant interaction and time effects for testosterone (F1,30  = 9.04, p = .005), free testosterone (F1,30  = 7.13, p = .012) and estradiol (F1,30  = 8.07, p = .008) levels in favour of the treatment group, while luteinising hormone, follicle-stimulating hormone and sexual hormone-binding globulin did not. The lack of changes in luteinising hormone and follicle-stimulating hormone levels suggests that a lesser role played by Eurycoma longifolia in activating the hypothalamic-pituitary-gonadal axis in the young adults. The raised testosterone level may be due to a greater rate of hormone production via the hypothalamic-pituitary-adrenal axis. The supplementation of Eurycoma longifolia for two weeks demonstrates steroidogenic effects on young men were dose-related. Consequently, the raised testosterone following Eurycoma longifolia supplementations could benefit muscle and strength gain in young adults.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Chan, KQ, Stewart, C, Chester, N, Hamzah, SH, Yusof, A. The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males. Andrologia. 2021; 00:e14001., which has been published in final form at https://dx.doi.org/10.1111/and.14001. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords: 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 16 Feb 2021 10:24
Last Modified: 04 Sep 2021 05:55
DOI or Identification number: 10.1111/and.14001
URI: https://researchonline.ljmu.ac.uk/id/eprint/14463

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