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Effects of statins on myocarditis: A review of underlying molecular mechanisms

Parsamanesh, N, Karami-Zarandi, M, Banach, M, Penson, PE and Sahebkar, A Effects of statins on myocarditis: A review of underlying molecular mechanisms. Progress in Cardiovascular Diseases. ISSN 0033-0620 (Accepted)

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Abstract

Myocarditis refers to the clinical and histological characteristics of a diverse range of inflammatory cellular pathophysiological conditions which result in cardiac dysfunction. Myocarditis is a major cause of mortality in individuals less than 40 years of age and accounts for approximately 20% of cardiovascular disease (CVD) events. Myocarditis contributes to dilated cardiomyopathy in 30% of patients and can progress to cardiac arrest, which has a poor prognosis of <40% survival over 10 years. Myocarditis has also been documented after infection with SARS-CoV-2. The most commonly used lipid-lowering therapies, HMG-CoA reductase inhibitors (statins), decrease CVD-related morbidity and mortality. In addition to their lipid-lowering effects, increasing evidence supports the existence of several additional beneficial, ‘pleiotropic’ effects of statins. Recently, several studies have indicated that statins may attenuate myocarditis. Statins modify the lipid oxidation, inflammation, immunomodulation, and endothelial activity of the pathophysiology and have been recommended as adjuvant treatment. In this review, we focus on the mechanisms of action of statins and their effects on myocarditis, SARS-CoV-2 and CVD.

Item Type: Article
Uncontrolled Keywords: 1102 Cardiorespiratory Medicine and Haematology
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 22 Feb 2021 11:01
Last Modified: 22 Feb 2021 11:01
DOI or Identification number: 10.1016/j.pcad.2021.02.008
URI: https://researchonline.ljmu.ac.uk/id/eprint/14497

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