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Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

Nahar, L, Al-Majmaie, S, Al-Groshi, A, Rasul, A and Sarker, SD (2021) Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential. Molecules, 26 (6). ISSN 1420-3049

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Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.

Item Type: Article
Uncontrolled Keywords: 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 0307 Theoretical and Computational Chemistry
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
Date Deposited: 17 Mar 2021 12:12
Last Modified: 04 Sep 2021 05:45
DOI or ID number: 10.3390/molecules26061609
URI: https://researchonline.ljmu.ac.uk/id/eprint/14636
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