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Genetic Polymorphisms Related to Vo2max Adaptation are Associated with Elite Rugby Union Status and Competitive Marathon Performance

Hall, ECR, Almeida, SS, Heffernan, SM, Lockey, SJ, Herbert, AJ, Callus, P, Day, SH, Pedlar, CR, Kipps, C, Collins, M, Pitsiladis, YP, Bennett, MA, Kilduff, LP, Stebbings, GK, Erskine, RM and Williams, AG (2021) Genetic Polymorphisms Related to Vo2max Adaptation are Associated with Elite Rugby Union Status and Competitive Marathon Performance. International Journal of Sports Physiology and Performance. ISSN 1555-0265

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Abstract

Purpose: Genetic polymorphisms have been associated with the adaptation to training in maximal oxygen uptake (V̇O2max). However, the genotype distribution of selected polymorphisms in athletic cohorts is unknown, with their influence on performance characteristics also undetermined. This study investigated whether the genotype distributions of three polymorphisms previously associated with V̇O2max training adaptation are associated with elite athlete status and performance characteristics in runners and rugby athletes, competitors for whom aerobic metabolism is important. Methods: Genomic DNA was collected from 732 men, including 165 long-distance runners, 212 elite rugby union athletes and 355 non-athletes. Genotype and allele frequencies of PRDM1 rs10499043 C/T, GRIN3A rs1535628 G/A and KCNH8 rs4973706 T/C were compared between athletes and non-athletes. Personal best marathon times in runners, as well as in-game performance variables and playing position of rugby athletes, were analysed according to genotype. Results: Runners with PRDM1 T alleles recorded marathon times ~3 min faster than CC homozygotes (02:27:55 ± 00:07:32 h vs. 02:31:03 ± 00:08:24 h, p = 0.023). Rugby athletes had 1.57 times greater odds of possessing the KCNH8 TT genotype than non-athletes (65.5% vs. 54.7%, χ2 = 6.494, p = 0.013). No other associations were identified. Conclusions: This study is the first to demonstrate that polymorphisms previously associated with V̇O2max training adaptations in non-athletes are also associated with marathon performance (PRDM1) and elite rugby union status (KCNH8). The genotypes and alleles previously associated with superior endurance training adaptation appear to be advantageous in long-distance running and achieving elite status in rugby union.

Item Type: Article
Additional Information: Manuscript has been published online as Ahead of Print: Accepted author manuscript version reprinted, by permission, from International Journal of Sports Physiology and Performance 2021 https://doi.org/10.1123/ijspp.2020-0856 © Human Kinetics, Inc
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology, 1701 Psychology
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Human Kinetics
Date Deposited: 25 Mar 2021 12:11
Last Modified: 14 Jun 2021 10:15
URI: https://researchonline.ljmu.ac.uk/id/eprint/14672

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