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The BDNF-Increasing Allele is Associated With Increased Proportion of Fast-Twitch Muscle Fibers, Handgrip Strength, and Power Athlete Status

Guilherme, JPLF, Semenova, EA, Borisov, OV, Kostryukova, ES, Vepkhvadze, TF, Lysenko, EA, Andryushchenko, ON, Andryushchenko, LB, Lednev, EM, Larin, AK, Bondareva, EA, Generozov, EV and Ahmetov, II The BDNF-Increasing Allele is Associated With Increased Proportion of Fast-Twitch Muscle Fibers, Handgrip Strength, and Power Athlete Status. Journal of Strength and Conditioning Research. ISSN 1064-8011 (Accepted)

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Abstract

The brain-derived neurotrophic factor (BDNF) is involved in neurogenesis and formation of regenerated myofibers following injury or damage. Recent study suggests that the BDNF overexpression increases the proportion of fast-twitch muscle fibers, while the BDNF deletion promotes a fast-to-slow transition. The purpose of this study was to evaluate the association between the BDNF gene rs10501089 polymorphism (associated with blood BDNF levels), muscle fiber composition and power athlete status. Muscle fiber composition was determined in 164 physically active individuals (113 males, 51 females). BDNF genotype and allele frequencies were compared between 508 Russian power athletes, 178 endurance athletes and 190 controls. We found that carriers of the minor A-allele (the BDNF-increasing allele) had significantly higher percentage of fast-twitch muscle fibers than individuals homozygous for the G-allele (males: 64.3 (7.8) vs. 50.3 (15.8)%, P = 0.0015; all participants: 64.1±7.9 vs. 49.6±14.7%, P = 0.0002). Furthermore, the A-allele was associated (P = 0.036) with greater handgrip strength in a sub-group of physically active subjects (n = 83) and over-represented in power athletes compared to controls (7.7 vs. 2.4%, P = 0.0001). The presence of the A-allele (i.e., AA+AG genotypes) rather than GG genotype increased the odds ratio of being a power athlete compared to controls (OR: 3.43, P = 0.00071) or endurance athletes (OR: 2.36, P = 0.0081). In conclusion, the rs10501089 A-allele is associated with increased proportion of fast-twitch muscle fibers and greater handgrip strength, and these may explain, in part, the association between the AA/AG genotypes and power athlete status.

Item Type: Article
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins
Date Deposited: 29 Mar 2021 09:34
Last Modified: 04 Sep 2021 05:42
DOI or Identification number: 10.1519/jsc.0000000000003756
URI: https://researchonline.ljmu.ac.uk/id/eprint/14696

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