Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza.

Wu, S, Zhu, B, Qin, L, Rahman, K, Zhang, L and Han, T (2021) Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza. Frontiers in Plant Science, 12. ISSN 1664-462X

[img]
Preview
Text
Transcription Factor A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza..pdf - Published Version
Available under License Creative Commons Attribution.

Download (338kB) | Preview

Abstract

Salvia miltiorrhiza Bunge is a common Chinese herbal medicine, and its major active ingredients are phenolic acids and tanshinones, which are widely used to treat vascular diseases. However, the wild form of S. miltiorrhiza possess low levels of these important pharmaceutical agents; thus, improving their levels is an active area of research. Transcription factors, which promote or inhibit the expressions of multiple genes involved in one or more biosynthetic pathways, are powerful tools for controlling gene expression in biosynthesis. Several families of transcription factors have been reported to participate in regulating phenolic acid and tanshinone biosynthesis and influence their accumulation. This review summarizes the current status in this field, with focus on the transcription factors which have been identified in recent years and their functions in the biosynthetic regulation of phenolic acids and tanshinones. Otherwise, the new insight for further research is provided. Finally, the application of the biosynthetic regulation of active ingredients by the transcription factors in S. miltiorrhiza are discussed, and new insights for future research are explored.

Item Type: Article
Uncontrolled Keywords: 0607 Plant Biology
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Frontiers Media
Related URLs:
Date Deposited: 29 Mar 2021 11:38
Last Modified: 29 Mar 2021 11:45
DOI or Identification number: 10.3389/fpls.2021.622011
URI: https://researchonline.ljmu.ac.uk/id/eprint/14707

Actions (login required)

View Item View Item