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An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery

Petkar, KC, Patil, SM, Chavhan, SS, Kaneko, K, Sawant, KK, Kunda, NK and Saleem, IY (2021) An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery. Pharmaceuticals, 13 (4). ISSN 1424-8247

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Abstract

The development of vaccines is one of the most significant medical accomplishments which has helped to eradicate a large number of diseases. It has undergone an evolutionary process from live attenuated pathogen vaccine to killed whole organisms or inactivated toxins (toxoids), each of them having its own advantages and disadvantages. The crucial parameters in vaccination are the generation of memory response and protection against infection, while an important aspect is the effective delivery of antigen in an intelligent manner to evoke a robust immune response. In this regard, nanotechnology is greatly contributing to developing efficient vaccine adjuvants and delivery systems. These can protect the encapsulated antigen from the host’s in-vivo environment and releasing it in a sustained manner to induce a long-lasting immunostimulatory effect. In view of this, the present review article summarizes nanoscale-based adjuvants and delivery vehicles such as viral vectors, virus-like particles and virosomes; non-viral vectors namely nanoemulsions, lipid nanocarriers, biodegradable and non-degradable nanoparticles, calcium phosphate nanoparticles, colloidally stable nanoparticles, proteosomes; and pattern recognition receptors covering c-type lectin receptors and toll-like receptors.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
Date Deposited: 30 Mar 2021 09:55
Last Modified: 30 Mar 2021 10:00
DOI or Identification number: 10.3390/pharmaceutics13040455
URI: https://researchonline.ljmu.ac.uk/id/eprint/14712

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