König, C, Honecker, B, Wilson, IW, Weedall, GD, Hall, N, Roeder, T, Metwally, NG and Bruchhaus, I (2021) Taxon-Specific Proteins of the Pathogenic Entamoeba Species E. histolytica and E. nuttalli. Frontiers in Cellular and Infection Microbiology, 11. ISSN 2235-2988

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Abstract

The human protozoan parasite Entamoeba histolytica can live in the human intestine for months or years without generating any symptoms in the host. For unknown reasons, amoebae can suddenly destroy the intestinal mucosa and become invasive. This can lead to amoebic colitis or extraintestinal amoebiasis whereby the amoebae spread to other organs the blood vessels, most commonly the liver where abscesses develop. Entamoeba nuttalli is the closest genetic relative of E. histolytica and is found in wild macaques. Another close relative is, which asyptomatically infects the human intestine. Although all three species are closely related, only E. histolytica and E. nuttalli are able to penetrate their host’s intestinal epithelium. Lineage-specific genes and gene families may hold the key to understanding differences in virulence among species. Here we discuss those genes found in that have relatives in only one or neither of its sister species, with particular focus on the peptidase, AIG, Ariel, and BspA families.

Item Type:	Article
Uncontrolled Keywords:	0601 Biochemistry and Cell Biology, 0605 Microbiology
Subjects:	G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology
Divisions:	Biological & Environmental Sciences (from Sep 19)
Publisher:	Frontiers Media
Date Deposited:	01 Apr 2021 11:03
Last Modified:	04 Sep 2021 05:39
DOI or ID number:	10.3389/fcimb.2021.641472
URI:	https://researchonline.ljmu.ac.uk/id/eprint/14737

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