Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

CD105 (Endoglin): A Potential Anticancer Therapeutic Inhibits Mitogenesis and Map Kinase Pathway Activation.

Liu, D, Kumar, S, Ashworth, J, Ali, K, Fadel, A, Guo, B and Slevin, M (2021) CD105 (Endoglin): A Potential Anticancer Therapeutic Inhibits Mitogenesis and Map Kinase Pathway Activation. Anticancer Research, 41 (3). pp. 1219-1229. ISSN 0250-7005

[img]
Preview
Text
Anticancer research.pdf - Published Version

Download (1MB) | Preview

Abstract

BACKGROUND: CD105 is highly expressed on human activated endothelial cells (ECs), is an important component of the TGF-β1 receptor complex and is essential for angiogenesis. CD105 expression is up-regulated in activated ECs and is an important potential marker for cancer prognosis. MATERIALS AND METHODS: In vitro rat myoblasts transfected with the L-CD105 and S-CD105 transfectants. The transfectants were treated with TGF-β1 for the angiogenesis study. RESULTS: L-CD105 affects cell proliferation in the presence and absence of TGF-β1, and inhibits p-ERK1/2, p-MEK1/2 and p-c-Jun in L-CD105 transfectants compared to controls. The induction of phospho-ERK1/2 following treatment with TGF-β1 remained significantly lower in L-CD105 transfectants compared to controls. CONCLUSION: L-CD105 inhibits the phosphorylation of ERK1/2, MEK1/2, c-Jun1/2/3, and associated signalling intermediates. CD105 modulates cell growth and TGF-β1 induced cell signalling through ERK-c-Jun expression.

Item Type: Article
Uncontrolled Keywords: CD105; MAPK; TGF-β1; angiogenesis; cell signalling
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RS Pharmacy and materia medica
Divisions: Sport & Exercise Sciences
Publisher: International Institute of Anticancer Research
Related URLs:
Date Deposited: 30 Apr 2021 10:11
Last Modified: 30 Apr 2021 10:11
DOI or Identification number: 10.21873/anticanres.14879
URI: https://researchonline.ljmu.ac.uk/id/eprint/14763

Actions (login required)

View Item View Item