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Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications.

Chen, Q, Lan, H-Y, Peng, W, Rahman, K, Liu, Q-C, Luan, X and Zhang, H (2021) Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications. Journal of Pharmacy and Pharmacology. ISSN 0022-3573

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Abstract

OBJECTIVES: Isatis indigotica Fort. (I. indigotica) is an herbaceous plant belonging to Cruciferae family. Its leaf (IIL) and root (IIR) are commonly used in traditional Chinese medicines (TCMs) with good clinical efficacies such as clearing away heat and detoxification, cooling blood and reducing swelling. This review aimed to provide a systematic summary on the phytochemistry, pharmacology and clinical applications of I. indigotica. KEY FINDINGS: This plant contains alkaloids, organic acids, flavonoids, lignans, nucleosides, amino acids, and steroids. Previous pharmacological researches indicated that I. indigotica possesses promising antivirus, antibacterial, immunoregulatory, anti-inflammation, and cholagogic effects. Importantly, it can inhibit various viruses, such as influenza, hepatitis B, mumps, herpes simplex, cytomegalovirus, and coxsachievirus. Clinically, it is frequently used to treat various viral diseases like viral influenza, parotitis and viral hepatitis. Consequently, I. indigotica may be beneficial for the prevention and treatment of coronavirus disease 2019 (COVID-19). SUMMARY: This paper reviewed the chemical constituents, pharmacological effects and clinical applications of I. indigotica which may guide further research and application of this plant.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Qiong Chen, Hai-Yue Lan, Wei Peng, Khalid Rahman, Qing-Chun Liu, Xin Luan, Hong Zhang, Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications, which has been published in final form at https://dx.doi.org/10.1093/jpp/rgab014. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences, 1116 Medical Physiology
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
R Medicine > RZ Other systems of medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 19 Apr 2021 10:41
Last Modified: 19 Apr 2021 10:41
DOI or Identification number: 10.1093/jpp/rgab014
URI: https://researchonline.ljmu.ac.uk/id/eprint/14818

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