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Hemodynamic and structural brain measures in high and low sedentary older adults.

Maasakkers, CM, Thijssen, DHJ, Knight, SP, Newman, L, O'Connor, JD, Scarlett, S, Carey, D, Buckley, A, McMorrow, JP, Leidhin, CN, Feeney, J, Melis, RJF, Kenny, RA, Claassen, JA and Looze, CD (2021) Hemodynamic and structural brain measures in high and low sedentary older adults. Journal of Cerebral Blood Flow & Metabolism. pp. 1-10. ISSN 0271-678X

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Abstract

Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed the association between sedentary behaviour and brain measures of cerebrovascular perfusion and structural abnormalities in community-dwelling older adults. Using accelerometery (GENEActiv) data from The Irish Longitudinal Study on Ageing (TILDA) we categorised individuals by low- and high-sedentary behaviour (≤8 vs >8 hours/day). We examined prefrontal haemoglobin oxygenation levels using Near-Infrared Spectroscopy during rest and after an orthostatic challenge in 718 individuals (66 ± 8 years, 52% female). Global grey matter cerebral blood flow, total grey and white matter volume, total and subfield hippocampal volumes, cortical thickness, and white matter hyperintensities were measured using arterial spin labelling, T1, and FLAIR MRI in 86 individuals (72 ± 6 years, 55% female). While no differences in prefrontal or global cerebral hemodynamics were found between groups, high-sedentary individuals showed lower hippocampal volumes and increased white matter hyperintensities compared to their low-sedentary counterparts. Since these structural cerebral abnormalities are associated with cognitive decline and Alzheimer's disease, future work exploring the causal pathways underlying these differences is needed.

Item Type: Article
Uncontrolled Keywords: 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1109 Neurosciences
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Sage
Related URLs:
Date Deposited: 30 Apr 2021 10:19
Last Modified: 30 Apr 2021 10:19
DOI or Identification number: 10.1177/0271678X211009382
URI: https://researchonline.ljmu.ac.uk/id/eprint/14896

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