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Intra-individual differences in the effect of endurance vs. Resistance training on vascular function: a cross-over study.

Dawson, EA, Sheikhsaraf, B, Boidin, M, Erskine, RM and Thijssen, DHJ Intra-individual differences in the effect of endurance vs. Resistance training on vascular function: a cross-over study. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188 (Accepted)

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Abstract

We used a within-subject, cross-over design study to compare the impact of 4-weeks' resistance (RT) versus endurance (END) training on vascular function. We subsequently explored the association of intra-individual effects of RT versus END on vascular function with a single nucleotide polymorphism (SNP) of the NOS3 gene. Thirty-five healthy males (21±2 years old) were genotyped for the NOS3 rs2070744 SNP and completed both training modalities. Participants completed 12 sessions over a 4-week period, either RT (leg-extension) or END (cycling) training in a randomised, balanced cross-over design with a 3 week washout period. Participants performed peak oxygen uptake (peak V ˙ O2 ) and leg-extension single-repetition maximum (1-RM) testing, and vascular function assessment using flow-mediated dilation (FMD) on 3 separated days pre/post training. Peak V ˙ O2 increased after END (P<0.001), while 1-RM increased after RT (P<0.001). FMD improved after 4-weeks' training (time-effect: P=0.006), with no difference between exercise modalities (interaction-effect: P=0.92). No relation was found between individual changes (delta, pre-post) in FMD to both types of training (R2 =0.06, P=0.14). Intra-individual changes in FMD following END and RT were associated with the NOS3 SNP, with TT homozygotes significantly favouring only END (P=0.016) and TC/CC tending to favour RT only (P=0.056). Although both training modes improved vascular function, significant intra-individual variation in the adaptation of FMD was found. The association with NOS3 genotype suggests a genetic predisposition to FMD adapting to a specific mode of chronic exercise. This study therefore provides novel evidence for personalised exercise training to optimise vascular health.

Item Type: Article
Additional Information: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/sms.13975
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 30 Apr 2021 11:13
Last Modified: 30 Apr 2021 11:13
DOI or Identification number: 10.1111/sms.13975
URI: https://researchonline.ljmu.ac.uk/id/eprint/14897

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