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Intra-individual differences in the effect of endurance vs. Resistance training on vascular function: a cross-over study.

Dawson, EA, Sheikhsaraf, B, Boidin, M, Erskine, RM and Thijssen, DHJ (2021) Intra-individual differences in the effect of endurance vs. Resistance training on vascular function: a cross-over study. Scandinavian Journal of Medicine & Science in Sports, 31 (8). pp. 1683-1692. ISSN 0905-7188

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We used a within-subject, cross-over design study to compare the impact of 4-weeks' resistance (RT) versus endurance (END) training on vascular function. We subsequently explored the association of intra-individual effects of RT versus END on vascular function with a single nucleotide polymorphism (SNP) of the NOS3 gene. Thirty-five healthy males (21±2 years old) were genotyped for the NOS3 rs2070744 SNP and completed both training modalities. Participants completed 12 sessions over a 4-week period, either RT (leg-extension) or END (cycling) training in a randomised, balanced cross-over design with a 3 week washout period. Participants performed peak oxygen uptake (peak V ˙ O2 ) and leg-extension single-repetition maximum (1-RM) testing, and vascular function assessment using flow-mediated dilation (FMD) on 3 separated days pre/post training. Peak V ˙ O2 increased after END (P<0.001), while 1-RM increased after RT (P<0.001). FMD improved after 4-weeks' training (time-effect: P=0.006), with no difference between exercise modalities (interaction-effect: P=0.92). No relation was found between individual changes (delta, pre-post) in FMD to both types of training (R2 =0.06, P=0.14). Intra-individual changes in FMD following END and RT were associated with the NOS3 SNP, with TT homozygotes significantly favouring only END (P=0.016) and TC/CC tending to favour RT only (P=0.056). Although both training modes improved vascular function, significant intra-individual variation in the adaptation of FMD was found. The association with NOS3 genotype suggests a genetic predisposition to FMD adapting to a specific mode of chronic exercise. This study therefore provides novel evidence for personalised exercise training to optimise vascular health.

Item Type: Article
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 30 Apr 2021 11:13
Last Modified: 07 Jan 2022 17:00
DOI or ID number: 10.1111/sms.13975
URI: https://researchonline.ljmu.ac.uk/id/eprint/14897
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