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The association between treatment and systemic inflammation in acromegaly.

Wolters, TLC, van der Heijden, CDCC, Pinzariu, O, Hijmans-Kersten, BTP, Jacobs, C, Kaffa, C, Hoischen, A, Netea, MG, Smit, JWA, Thijssen, DHJ, Georgescu, CE, Riksen, NP and Netea-Maier, RT (2021) The association between treatment and systemic inflammation in acromegaly. Growth Hormone and IGF Research, 57-58. ISSN 1096-6374

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Abstract

OBJECTIVE: Acromegaly is characterized by an excess of growth hormone (GH) and insulin like growth-factor 1 (IGF1), and it is strongly associated with cardiovascular diseases (CVD). Both acute and long-lasting pro-inflammatory effects have been attributed to IGF1. Previous results suggest the presence of systemic inflammation in treated patients. Here we assessed the association between treatment of acromegaly, systemic inflammation and vascular function. DESIGN: Ex vivo cytokine production and circulating inflammatory markers were assessed in peripheral blood from treated and untreated acromegaly patients (N = 120), and compared them with healthy controls. A more comprehensive prospective inflammatory and vascular assessment was conducted in a subgroup of six treatment-naive patients with follow-up during treatment. RESULTS: Circulating concentrations of VCAM1, E-selectin and MMP2 were higher in patients with uncontrolled disease, whereas the concentrations of IL18 were lower. In stimulated whole blood, cytokine production was skewed towards a more pro-inflammatory profile in patients, especially those with untreated disease. Prospective vascular measurements in untreated patients showed improvement of endothelial function during treatment. CONCLUSIONS: Acromegaly patients are characterized by a pro-inflammatory phenotype, most pronounced in those with uncontrolled disease. Treatment only partially reverses this pro-inflammatory bias. These findings suggest that systemic inflammation could contribute to the increased risk of CVD in acromegaly patients.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology, 0606 Physiology, 1101 Medical Biochemistry and Metabolomics
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: Sport & Exercise Sciences
Publisher: Elsevier
Related URLs:
Date Deposited: 10 May 2021 10:41
Last Modified: 10 May 2021 10:45
DOI or Identification number: 10.1016/j.ghir.2021.101391
URI: https://researchonline.ljmu.ac.uk/id/eprint/14970

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