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Androgen receptor gene microsatellite polymorphism is associated with muscle mass and strength in bodybuilders and power athlete status

Guilherme, JPLF, V. Shikhova, Y, R. Dondukovskaya, R, A. Topanova, A, A. Semenova, E, V. Astratenkova, I and Ahmetov, II (2021) Androgen receptor gene microsatellite polymorphism is associated with muscle mass and strength in bodybuilders and power athlete status. Annals of Human Biology, 48 (2). pp. 142-149. ISSN 0301-4460

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Abstract

Background: The androgen receptor (AR) gene contains a polymorphic trinucleotide (CAG) microsatellite repeat sequence (short or long alleles) that has been associated with fat-free mass in untrained men, which needs to be replicated in athletic cohorts.
Aim: The purpose of this study was to explore the AR (CAG) polymorphism in trained individuals.
Subjects and methods: A total of 61 professional bodybuilders (40 males, 21 females), 73 elite male sprinters and weightlifters and 186 male controls were enrolled in this study. The influence of the AR (CAG) polymorphism on muscle mass and strength was assessed in bodybuilders, while the frequencies of AR (CAG) alleles were compared between power athletes and non-athletes.
Results: The polymorphism was associated with anthropometric and strength measurements in bodybuilders of both genders. Those with ≥21 CAG repeats (i.e. carriers of long alleles) exhibited greater (p < 0.05) body mass index, absolute muscle mass, arm/thigh circumference and upper/lower limb strength compared to those with <21 CAG repeats. Furthermore, carriers of ≥21 CAG repeats were more frequent among power athletes compared to controls (p = 0.0076).
Conclusions: Long alleles of the AR (CAG) polymorphism were associated with greater muscle mass and strength in bodybuilders, and power athlete status.

Item Type: Article
Additional Information: “This is an Accepted Manuscript version of the following article, accepted for publication in Annals of Human Biology. João Paulo L. F. Guilherme, Yulia V. Shikhova, Rimma R. Dondukovskaya, Alexandra A. Topanova, Ekaterina A. Semenova, Irina V. Astratenkova & Ildus I. Ahmetov (2021) Androgen receptor gene microsatellite polymorphism is associated with muscle mass and strength in bodybuilders and power athlete status, Annals of Human Biology, 48:2, 142-149, DOI: 10.1080/03014460.2021.1919204. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Taylor & Francis
Date Deposited: 10 Jun 2021 09:48
Last Modified: 10 Jun 2021 09:48
DOI or Identification number: 10.1080/03014460.2021.1919204
URI: https://researchonline.ljmu.ac.uk/id/eprint/15126

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