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Timed daily exercise remodels circadian rhythms in mice

Hughes, ATL, Samuels, RE, Baño-Otálora, B, Belle, MDC, Wegner, S, Guilding, C, Northeast, RC, Loudon, ASI, Gigg, J and Piggins, HD (2021) Timed daily exercise remodels circadian rhythms in mice. Communications Biology, 4 (1). ISSN 2399-3642

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Open Access URL: https://www.nature.com/articles/s42003-021-02239-2 (Published version)

Abstract

Regular exercise is important for physical and mental health. An underexplored and intriguing property of exercise is its actions on the body’s 24 h or circadian rhythms. Molecular clock cells in the brain’s suprachiasmatic nuclei (SCN) use electrical and chemical signals to orchestrate their activity and convey time of day information to the rest of the brain and body. To date, the long-lasting effects of regular physical exercise on SCN clock cell coordination and communication remain unresolved. Utilizing mouse models in which SCN intercellular neuropeptide signaling is impaired as well as those with intact SCN neurochemical signaling, we examined how daily scheduled voluntary exercise (SVE) influenced behavioral rhythms and SCN molecular and neuronal activities. We show that in mice with disrupted neuropeptide signaling, SVE promotes SCN clock cell synchrony and robust 24 h rhythms in behavior. Interestingly, in both intact and neuropeptide signaling deficient animals, SVE reduces SCN neural activity and alters GABAergic signaling. These findings illustrate the potential utility of regular exercise as a long-lasting and effective non-invasive intervention in the elderly or mentally ill where circadian rhythms can be blunted and poorly aligned to the external world.

Item Type: Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QH Natural history > QH301 Biology
Divisions: Biological & Environmental Sciences (new Sep 19)
Publisher: Nature Publishing Group
Date Deposited: 21 Jun 2021 10:06
Last Modified: 21 Jun 2021 10:15
DOI or Identification number: 10.1038/s42003-021-02239-2
URI: https://researchonline.ljmu.ac.uk/id/eprint/15151

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