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Statins as anti-pyroptotic agents

Khalifeh, M, Penson, P, Banach, M and Sahebkar, A Statins as anti-pyroptotic agents. Archives of Medical Science. ISSN 1734-1922 (Accepted)

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Abstract

Pyroptosis is a regulated form of cell death, which is often a consequence of the activation of inflammatory caspases. Appropriate inflammatory responses and the induction of pyroptosis enhance the clearance of pathogens and increase innate immunity. However, excessive pyroptosis contributes to a hyperinflammatory response and aggravates tissue damage, thereby causing inflammatory diseases. There have been reports on the modulation of pyroptosis by statins, which may explain part of the pleiotropic actions of these drugs in inflammatory diseases and cancer. Herein, the extant evidence for the potential value of statins in targeting pyroptosis in various diseases is reviewed.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Termedia Publishing House
Date Deposited: 19 Aug 2021 10:48
Last Modified: 04 Sep 2021 05:07
DOI or Identification number: 10.5114/aoms/141155
URI: https://researchonline.ljmu.ac.uk/id/eprint/15389

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