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Prevalence and factors associated with chronic venous insufficiency, leg ulceration and deep-vein thrombosis among people who inject drugs in London, United Kingdom

Doran, J, Hope, V, Wright, T, Scott, J, Ciccarone,, D and Harris, M Prevalence and factors associated with chronic venous insufficiency, leg ulceration and deep-vein thrombosis among people who inject drugs in London, United Kingdom. Drug and Alcohol Review. ISSN 0959-5236 (Accepted)

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Abstract

Introduction. People who inject drugs (PWID) are vulnerable to a range of harms, including vascular conditions such as chronic venous insufficiency (CVI), leg ulcers and deep-vein thrombosis (DVT). The extent of vascular conditions has rarely been studied, despite contributing to considerable illness and disability among PWID. We assess the prevalence and associations of vascular conditions in PWID in London, UK.
Methods. Survey-data from the community-recruited Care and Prevent Study of PWID in London were analysed. Participants were asked about CVI and leg ulcers using pictorialquestions, and if they had ever been diagnosed with DVT. Associations between vascularconditions and demographic/drug-use information were explored using univariate and multivariable logistic regression.
Results. Among participants (n=455), the prevalence of CVI, leg ulcers and DVT was 13% (n=57), 10% (n=46) and 23% (n=105), respectively. CVI and DVT were positively associated with injecting into the groin, while injecting into the leg was positively associated with leg ulcers and DVT. CVI was also associated with not cleaning injection sites and diagnosed hepatitis C virus; and DVT with hepatitis C virus.
Discussion and Conclusion. The prevalence of vascular problems among PWID in London is very high in comparison to the general population. These conditions are primarily associated with injection into the femoral vein. Use of these injection sites indicate peripheral venous access problems. There is a need to reinvigorate safe injection information provision in harm reduction services, with attention to reducing risk practices associated with venous-damage and transitions to femoral injection.

Item Type: Article
Additional Information: Embargo requested: Not known
Uncontrolled Keywords: 11 Medical and Health Sciences, 16 Studies in Human Society, 17 Psychology and Cognitive Sciences
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Public Health Institute
Publisher: Wiley
Date Deposited: 24 Sep 2021 12:15
Last Modified: 24 Sep 2021 12:15
URI: https://researchonline.ljmu.ac.uk/id/eprint/15547

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