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Physical activity and fat-free mass during growth and in later life.

Westerterp, KR, Yamada, Y, Sagayama, H, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SGJA, Close, GL, Cooper, JA, Das, SK , Cooper, R, Dugas, LR, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Martin, CK, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Pietiläinen, KH, Pitsiladis, YP, Plange-Rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, J, Yoshida, T, Zhang, X, Murphy-Alford, AJ, Loechl, CU, Luke, AH, Pontzer, H, Rood, J, Schoeller, DA, Wong, WW, Speakman, JR and International Atomic Energy Agency Doubly Labeled Water database, (2021) Physical activity and fat-free mass during growth and in later life. American Journal of Clinical Nutrition. ISSN 1938-3207

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Abstract

BACKGROUND: Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. OBJECTIVES: A study is presented of the association between FFM and physical activity in relation to age. METHODS: In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution. RESULTS: PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males < 18 y old, and 32% and 47% of the variation in FFM in females and males ≥ 18 y old, respectively. In participants < 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM-adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: -0.2, 1.7 kg) and 1.0 kg (95% CI: -0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively. CONCLUSIONS: If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.

Item Type: Article
Uncontrolled Keywords: 09 Engineering, 11 Medical and Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Oxford University Press (OUP)
Related URLs:
Date Deposited: 27 Sep 2021 08:25
Last Modified: 27 Sep 2021 08:30
DOI or ID number: 10.1093/ajcn/nqab260
URI: https://researchonline.ljmu.ac.uk/id/eprint/15548
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