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Anti-infective dyes in the time of COVID

Wainwright, M (2021) Anti-infective dyes in the time of COVID. Dyes and Pigments, 196. ISSN 0143-7208

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Abstract

The phenomenal global upheaval caused by SARS-CoV-2 has produced amazing responses from science and healthcare, particularly in the rapid realisation and production of vaccines. However, until early 2020 global infection control research was highly focused on rapidly increasing rates of conventional antimicrobial resistance (AMR) and the supply of drugs to counter this. Antimicrobial dyes have been suggested by various authors for inclusion in this effort, usually with little return from responsible authorities, and normally on the basis of post-treatment staining or potential toxicity, but this does not deny the fact that such dyes, particularly with photoactivation, are the only class of agents with pan-microbial activity – i.e. against each of bacteria, viruses, fungi and protozoa – regardless of the organism's drug resistance status. Conventional antibacterials, antivirals etc. usually demonstrate activity against one particular section of pathogens only, and disinfectants such as chlorhexidine or benzalkonium salts are too toxic for internal use. This perspective reflects both the background utility of antimicrobial dyes and ways forward for their inclusion in 21st Century infection control protocols.

Item Type: Article
Uncontrolled Keywords: 0306 Physical Chemistry (incl. Structural), 0904 Chemical Engineering
Subjects: Q Science > QD Chemistry
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 27 Sep 2021 12:02
Last Modified: 27 Sep 2021 12:02
DOI or Identification number: 10.1016/j.dyepig.2021.109813
URI: https://researchonline.ljmu.ac.uk/id/eprint/15561

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