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High-intensity interval training in polycystic ovary syndrome: a two-centre, three-armed randomized controlled trial

Kiel, IA, Lionet, S, Parr, EB, Jones, H, Røset, MAH, Salvesen, Ø, Hawley, J, Vanky, E and Moholdt, T (2022) High-intensity interval training in polycystic ovary syndrome: a two-centre, three-armed randomized controlled trial. Medicine and Science in Sports and Exercise. ISSN 0195-9131

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Purpose: Exercise training is recommended to improve cardiometabolic health and fertility in women with polycystic ovary syndrome (PCOS), yet there are few randomized controlled trials on the effects of different exercise protocols on clinical reproductive outcomes. Our aim was to determine the effect of high-intensity interval training (HIT) on menstrual frequency, as a proxy of reproductive function, in women with PCOS.
Methods: The IMPROV-IT study was a two-centre randomized controlled trial undertaken in Norway and Australia. Women with PCOS were eligible for inclusion. After stratification for body mass index < or ≥27 kg/m2 and study centre, participants were randomly allocated (1:1:1) to high-volume HIT (HV-HIT), low-volume HIT (LV-HIT), or a control group. Measurements were assessed at baseline, after the 16-week exercise intervention and at 12-months follow-up. The primary outcome was menstrual frequency after 12 months. Secondary outcomes included markers of cardiometabolic and reproductive health, quality of life, and adherence to and enjoyment of HIT.
Results: We randomly allocated 64 participants to HV-HIT (n=20), LV-HIT (n=21), or the control group (n=23). There were no differences in menstrual frequency at 12 months between LV-HIT and control (frequency-ratio 42 1.02, 95% CI 0.73-1.), HV-HIT and control (frequency-ratio 0.93, 95% CI 0.67-1.29) or LV-HIT and HV-HIT (frequency-ratio 1.09, 95% CI 0.77-1.56). Menstrual frequency increased in all groups from baseline to 12 months. More participants became pregnant in the LV-HIT group (n=5) than in the control group (n=0, p=0.02).
Conclusion: A semi-supervised HIT intervention did not increase menstrual frequency in women with PCOS.

Item Type: Article
Additional Information: This is an author accepted version of the following paper: Kiel, Ida A.1,2; Lionett, Sofie1,2,3; Parr, Evelyn B.3; Jones, Helen4; Røset, Maria A. H.2; Salvesen, Øyvind5; Hawley, John A.3; Vanky, Eszter2; Moholdt, Trine1,2 High-Intensity Interval Training in Polycystic Ovary Syndrome, Medicine & Science in Sports & Exercise: January 12, 2022 - Volume - Issue - doi: 10.1249/MSS.0000000000002849
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology, 1117 Public Health and Health Services
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins
Date Deposited: 08 Dec 2021 10:51
Last Modified: 12 Jan 2023 00:50
DOI or ID number: 10.1249/MSS.0000000000002849
URI: https://researchonline.ljmu.ac.uk/id/eprint/15898
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