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The association of Human Leukocyte Antigens Complex with Type 1 Diabetes in Omanis

Al-Balushi, M, Al-Badi, S, Al-Yaarubi, S, Al-Riyami, H, Al-Shidhani, A, Al-Hinai, S, Alshirawi, A, Hasson, SS, Said, E, Al-Jabri, A and Al Ansari, A (2022) The association of Human Leukocyte Antigens Complex with Type 1 Diabetes in Omanis. Sultan Qaboos University Medical Journal [SQUMJ]. ISSN 2075-0528

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Abstract

Background: Identifying the human leukocyte antigens (HLA) high risk alleles, genotypes and haplotypes in different populations is beneficial for understanding their roles in type 1 diabetes (T1D) pathogenesis and intervention practices. Objective: The aim of this study was to identify T1D associated HLA gene alleles in the Omani population. Methods: Our case-control study included 73 diabetic seropositive children (mean age 9.08±3.27 years) and 110 healthy controls. HLA–A, -B, -C, -DRB1, and -DQB1 genes were genotyped using sequence specific primer polymerase chain reaction (SSP-PCR). Results: Two HLA class I alleles (B*08, B*58) and three class II alleles (DQB1*02, DRB1*03 and DRB1*04) were associated with T1D susceptibility, while one class I (B*51) and three class II (DQB1*05, DQB1*06, and DRB1*16) alleles were associated with T1D protection. HLA- DRB1*03 and DQB1*02 alleles showed the strongest risk association among all alleles. Six DRB1 residues (E9, S11, S13, Y30, V70 and K71) were significantly associated with T1D susceptibility. Heterozygous genotypes, HLA-DRB1*03/*04 and DQB1*02/*03 were significantly associated with T1D susceptibility (P=4.29E-07, OR=63.2 and P=0.02, OR=3.6, respectively). Furthermore, we detected a significant combined action of DRB1*03-DQB1*02 haplotype in T1D risk (P=1.76E-05, OR=15), and DRB1*16-DQB1*05 haplotype in protection (P=3.12E-2, OR=0.48). Conclusion: Known HLA class II gene alleles are associated with T1D in Omani children.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences, 1117 Public Health and Health Services
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Sultan Qaboos University
Date Deposited: 21 Feb 2022 10:14
Last Modified: 21 Feb 2022 10:14
DOI or Identification number: 10.18295/squmj.2.2022.016
URI: https://researchonline.ljmu.ac.uk/id/eprint/16342

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