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Razmovski-Naumovski, V, Zhou, X, Wong, HY, Kam, A, Pearson, J and Chan, K (2020) Chromatographic, Chemometric and Antioxidant Assessment of the Equivalence of Granules and Herbal Materials of Angelicae sinensis Radix. Medicines (Basel), 7 (6). ISSN 2305-6320
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Chromatographic, Chemometric and Antioxidant Assessment of the Equivalence of Granules and Herbal Materials of iAngelicae si.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Background: Granules are a popular way of administrating herbal decoctions. However, there are no standardised quality control methods for granules, with few studies comparing the granules to traditional herbal decoctions. This study developed a multi-analytical platform to compare the quality of granule products to herb/decoction pieces of Angelicae Sinensis Radix (Danggui). Methods: A validated ultra-performance liquid chromatography coupled with photodiode array detector (UPLC-PDA) method quantitatively compared the aqueous extracts. Hierarchical agglomerative clustering analysis (HCA) and principal component analysis (PCA) clustered the samples according to three chemical compounds: ferulic acid, caffeic acid and Z-ligustilide. Ferric ion-reducing antioxidant power (FRAP) and 2,2-Diphenyl-1-picrylhydrazyl radical scavenging capacity (DPPH) assessed the antioxidant activity of the samples. Results: HCA and PCA allocated the samples into two main groups: granule products and herb/decoction pieces. Greater differentiation between the samples was obtained with three chemical markers compared to using one marker. The herb/decoction pieces group showed comparatively higher extraction yields and significantly higher DPPH and FRAP (p < 0.05), which was positively correlated to caffeic acid and ferulic acid, respectively. Conclusions: The results confirm the need for the quality assessment of granule products using more than one chemical marker for widespread practitioner and consumer use.
| Item Type: | Article |
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| Uncontrolled Keywords: | Angelicae sinensis radix; Danggui; antioxidant; granules; herb; multivariate analysis; ultra-performance liquid chromatography |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | MDPI |
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| Date Deposited: | 21 Feb 2022 12:44 |
| Last Modified: | 21 Feb 2022 12:44 |
| DOI or ID number: | 10.3390/medicines7060035 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16361 |
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