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Smith, TJ, Wilson, M, Whitney, C, Fagnant, H, Neumeier, WH, Smith, C, Heaton, KJ, Cho, E, Spielmann, G, Walsh, NP and Karl, JP (2022) Supplemental Protein and a Multi-Nutrient Beverage Speed Wound Healing Following Acute Sleep Restriction in Healthy Adults. The Journal of Nutrition. ISSN 0022-3166
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Smith Walsh 2022_ Supplemental Protein and Multi-Nutrient Beverage Speed Wound Healing following Acute Sleep Restriction_ J Nutrn.pdf - Accepted Version Download (1MB) | Preview |
Abstract
BACKGROUND: Physiological and psychological stress slow healing from experimental wounds by impairing immune function. OBJECTIVE: To determine whether supplemental protein and multi-nutrient supplementation improve wound healing markers following acute stress induced by acute sleep restriction. METHODS: In this single-blind, cross-over study of generally healthy young adults (18 males/2 females; 19.7±2.30 years [mean±SD]), experimental wounds were created by removing the top layer of forearm blisters induced via suction after 48-h of 72-h sleep restriction (2-h nightly sleep), a protocol previously shown to delay wound healing. Skin barrier restoration (measured by trans-epidermal water loss, TEWL) assessed wound healing up to 10 days post-blistering, and local immune responses were evaluated by serial measurement of cytokine concentrations in fluid collected at wound sites for 48-h post-blistering. Participants consumed controlled, isocaloric diets with either 0.900 g·kg-1·d-1 protein plus placebo (PLA) or 1.50 g·kg-1·d-1 protein plus multi-nutrient beverage (NUT; L-arginine: 20.0 g·d-1, L-glutamine: 30.0 g·d-1, omega-3 fatty acids: 1.00 g·d-1, zinc sulfate: 24.0 mg·d-1, cholecalciferol: 800 IU·d-1 and vitamin C: 400 mg·d-1) during sleep restriction and for 4 days afterwards. RESULTS: Skin barrier restoration (primary outcome) was shorter for NUT [(median, interquartile range) (3.98, 1.17 days)] compared to PLA (5.25, 1.05 days) (P = 0.001). Cytokines from wound fluid (secondary outcome) increased over time (main effect of time P≤0.001), except IL-13 (P = 0.07); however, no effects of treatment were observed. CONCLUSIONS: Supplemental nutrition may promote wound healing following sleep restriction in healthy adults including military personnel, the latter of which also have a high incidence of wounds and infection. Clinical trials registration: clinicaltrials.gov #NCT03525184.
| Item Type: | Article |
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| Additional Information: | This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Nutrition following peer review. The version of record Tracey J Smith, Marques Wilson, Claire Whitney, Heather Fagnant, William H Neumeier, Carl Smith, Kristin J Heaton, Eunhan Cho, Guillaume Spielmann, Neil P Walsh, J Philip Karl, Supplemental Protein and a Multi-Nutrient Beverage Speed Wound Healing Following Acute Sleep Restriction in Healthy Adults, The Journal of Nutrition, 2022;, nxac064 is available online at: https://doi.org/10.1093/jn/nxac064 |
| Uncontrolled Keywords: | 0702 Animal Production, 0908 Food Sciences, 1111 Nutrition and Dietetics |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American Society for Nutrition |
| Related URLs: | |
| Date Deposited: | 18 Mar 2022 13:27 |
| Last Modified: | 14 Mar 2023 00:51 |
| DOI or ID number: | 10.1093/jn/nxac064 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16515 |
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