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Supplemental Protein and a Multi-Nutrient Beverage Speed Wound Healing Following Acute Sleep Restriction in Healthy Adults.

Smith, TJ, Wilson, M, Whitney, C, Fagnant, H, Neumeier, WH, Smith, C, Heaton, KJ, Cho, E, Spielmann, G, Walsh, NP and Karl, JP (2022) Supplemental Protein and a Multi-Nutrient Beverage Speed Wound Healing Following Acute Sleep Restriction in Healthy Adults. The Journal of Nutrition. ISSN 0022-3166

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Smith Walsh 2022_ Supplemental Protein and Multi-Nutrient Beverage Speed Wound Healing following Acute Sleep Restriction_ J Nutrn.pdf - Accepted Version
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Abstract

BACKGROUND: Physiological and psychological stress slow healing from experimental wounds by impairing immune function. OBJECTIVE: To determine whether supplemental protein and multi-nutrient supplementation improve wound healing markers following acute stress induced by acute sleep restriction. METHODS: In this single-blind, cross-over study of generally healthy young adults (18 males/2 females; 19.7±2.30 years [mean±SD]), experimental wounds were created by removing the top layer of forearm blisters induced via suction after 48-h of 72-h sleep restriction (2-h nightly sleep), a protocol previously shown to delay wound healing. Skin barrier restoration (measured by trans-epidermal water loss, TEWL) assessed wound healing up to 10 days post-blistering, and local immune responses were evaluated by serial measurement of cytokine concentrations in fluid collected at wound sites for 48-h post-blistering. Participants consumed controlled, isocaloric diets with either 0.900 g·kg-1·d-1 protein plus placebo (PLA) or 1.50 g·kg-1·d-1 protein plus multi-nutrient beverage (NUT; L-arginine: 20.0 g·d-1, L-glutamine: 30.0 g·d-1, omega-3 fatty acids: 1.00 g·d-1, zinc sulfate: 24.0 mg·d-1, cholecalciferol: 800 IU·d-1 and vitamin C: 400 mg·d-1) during sleep restriction and for 4 days afterwards. RESULTS: Skin barrier restoration (primary outcome) was shorter for NUT [(median, interquartile range) (3.98, 1.17 days)] compared to PLA (5.25, 1.05 days) (P = 0.001). Cytokines from wound fluid (secondary outcome) increased over time (main effect of time P≤0.001), except IL-13 (P = 0.07); however, no effects of treatment were observed. CONCLUSIONS: Supplemental nutrition may promote wound healing following sleep restriction in healthy adults including military personnel, the latter of which also have a high incidence of wounds and infection. Clinical trials registration: clinicaltrials.gov #NCT03525184.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Nutrition following peer review. The version of record Tracey J Smith, Marques Wilson, Claire Whitney, Heather Fagnant, William H Neumeier, Carl Smith, Kristin J Heaton, Eunhan Cho, Guillaume Spielmann, Neil P Walsh, J Philip Karl, Supplemental Protein and a Multi-Nutrient Beverage Speed Wound Healing Following Acute Sleep Restriction in Healthy Adults, The Journal of Nutrition, 2022;, nxac064 is available online at: https://doi.org/10.1093/jn/nxac064
Uncontrolled Keywords: 0702 Animal Production, 0908 Food Sciences, 1111 Nutrition and Dietetics
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American Society for Nutrition
Related URLs:
Date Deposited: 18 Mar 2022 13:27
Last Modified: 05 Apr 2022 09:15
DOI or Identification number: 10.1093/jn/nxac064
URI: https://researchonline.ljmu.ac.uk/id/eprint/16515

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