Gineviciene, V, Utkus, A, Pranckeviciene, E, Semenova, EA, Hall, ECR and Ahmetov, II (2022) Perspectives in Sports Genomics. Biomedicines, 10 (2). ISSN 2227-9059

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Abstract

Human athletic performance is a complex phenotype influenced by environmental and genetic factors, with most exercise-related traits being polygenic in nature. The aim of this article is to outline some of the challenge faced by sports genetics as this relatively new field moves forward. This review summarizes recent advances in sports science and discusses the impact of the genome, epigenome and other omics (such as proteomics and metabolomics) on athletic performance. The article also highlights the current status of gene doping and examines the possibility of applying genetic knowledge to predict athletes’ injury risk and to prevent the rare but alarming occurrence of sudden deaths during sporting events. Future research in large cohorts of athletes has the potential to detect new genetic variants and to confirm the previously identified DNA variants believed to explain the natural predisposition of some individuals to certain athletic abilities and health benefits. It is hoped that this article will be useful to sports scientists who seek a greater understanding of how genetics influences exercise science and how genomic and other multi-omics approaches might support performance analysis, coaching, personalizing nutrition, rehabilitation and sports medicine, as well as the potential to develop new rationale for future scientific investigation.

Item Type:	Article
Uncontrolled Keywords:	Science & Technology; Life Sciences & Biomedicine; Biochemistry & Molecular Biology; Medicine, Research & Experimental; Pharmacology & Pharmacy; Research & Experimental Medicine; sports science; sports genetics; omics; bioinformatics; physical performance; athletes; injury prevention; gene doping; SUDDEN CARDIAC DEATH; ATHLETE STATUS; GENE; EXERCISE; POLYMORPHISMS; PERFORMANCE; SCORE; ASSOCIATION; ADAPTATION; MYOSTATIN
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	MDPI
Related URLs:	Author
Date Deposited:	06 Apr 2022 11:02
Last Modified:	06 Apr 2022 11:15
DOI or ID number:	10.3390/biomedicines10020298
URI:	https://researchonline.ljmu.ac.uk/id/eprint/16604

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