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Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study

Bruno, D, Jauregi, A, Pomara, N, Zetterberg, H, Blennow, K, Koscik, R, Carlsson, C, Bendlin, B, Okonkwo, O, Hermann, B, Johnson, S and Mueller, K Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study. Neuropsychology. ISSN 0894-4105 (Accepted)

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Abstract

Objective: The preeminent in-vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) are amyloid β 1-42 (Aβ42), p-tau and t-tau. The goal of this study was to examine how well traditional (total and delayed recall) and process-based (recency ratio; Rr) measures derived from Rey’s AVLT were associated with these biomarkers.
Method: Data from 235 participants (mean age = 65.5, SD = 6.9), who ranged from cognitively unimpaired to mild cognitive impairment, and for whom CSF values were available, were extracted from the Wisconsin Registry for Alzheimer’s Prevention. Bayesian regression analyses were carried out using CSF scores as outcomes, AVLT scores as predictors, and controlling for demographic data and diagnosis.
Results: We found moderate evidence that Rr was associated with both CSF p-tau (BFm = 5.55;) and t-tau (BFm = 7.28), above and beyond the control variables, while it did not correlate with CSF Aβ42 levels. In contrast, total and delayed recall scores were not linked with any of the AD biomarkers, in separate analyses. When comparing all memory predictors in a single regression, Rr remained the strongest predictor of CSF t-tau levels (BFm = 3.57).
Conclusions: Our findings suggest that Rr may be a better cognitive measure than commonly used AVLT scores to assess CSF levels of p-tau and t-tau in non-demented individuals.

Item Type: Article
Additional Information: This is the accepted version of an article to be published in: Neuropsychology.
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (new Sep 2019)
Publisher: American Psychological Association
SWORD Depositor: A Symplectic
Date Deposited: 28 Apr 2022 09:37
Last Modified: 28 Apr 2022 09:45
URI: https://researchonline.ljmu.ac.uk/id/eprint/16723

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