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Thoma, A, Akter-Miah, T, Reade, RL and Lightfoot, AP (2020) Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function. Biogerontology, 21 (4). pp. 475-484. ISSN 1389-5729
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Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function.pdf - Published Version Available under License Creative Commons Attribution. Download (410kB) | Preview |
Abstract
The loss of muscle mass and function with age, termed sarcopenia, is an inevitable process, which has a significant impact on quality of life. During ageing we observe a progressive loss of total muscle fibres and a reduction in cross-sectional area of the remaining fibres, resulting in a significant reduction in force output. The mechanisms which underpin sarcopenia are complex and poorly understood, ranging from inflammation, dysregulation of protein metabolism and denervation. However, there is significant evidence to demonstrate that modified ROS generation, redox dis-homeostasis and mitochondrial dysfunction may have an important role to play. Based on this, significant interest and research has interrogated potential ROS-targeted therapies, ranging from nutritional-based interventions such as vitamin E/C, polyphenols (resveratrol) and targeted pharmacological compounds, using molecules such as SS-31 and MitoQ. In this review we evaluate these approaches to target aberrant age-related ROS generation and the impact on muscle mass and function.
| Item Type: | Article |
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| Uncontrolled Keywords: | Muscles; Humans; Reactive Oxygen Species; Oxidative Stress; Aging; Quality of Life; Sarcopenia; Ageing; Mitochondria; Oxidative stress; Reactive oxygen species; Sarcopenia; Aging; Humans; Muscles; Oxidative Stress; Quality of Life; Reactive Oxygen Species; Sarcopenia; Gerontology; 1103 Clinical Sciences |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Springer |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 12 May 2022 11:36 |
| Last Modified: | 12 May 2022 11:36 |
| DOI or ID number: | 10.1007/s10522-020-09883-x |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16833 |
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