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Watson, JA, Ryan, CG, Atkinson, G, Williamson, P, Ellington, D, Whittle, R, Dixon, J and Martin, DJ (2020) Inter-Individual Differences in the Responses to Pain Neuroscience Education in Adults With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The Journal of Pain, 22 (1). pp. 9-20. ISSN 1526-5900
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Abstract
Pain neuroscience education (PNE) is an approach used in the management of chronic musculoskeletal pain. Previous reviews on PNE and other pain interventions, have focused on mean treatment effects, but in the context of “precision medicine,” any inter-individual differences in treatment response are also important to quantify. If inter-individual differences are present, and predictors identified, PNE could be tailored to certain people for optimizing effectiveness. Such heterogeneity can be quantified using recently formulated approaches for comparing the response variance between the treatment and control groups. Therefore, we conducted a systematic review and meta-analysis on the extracted standard deviations of baseline-to-follow up change to quantify the inter-individual variation in pain, disability and psychosocial outcomes in response to PNE. Electronic databases were searched between January 1, 2002 and June 14, 2018. The review included 5 randomized controlled trials (n = 428) in which disability outcomes were reported. Using a random effects meta-analysis, the pooled SD (95% confidence interval) for control group-adjusted response heterogeneity to PNE was 7.36 units /100 (95% confidence interval = −3.93 to 11.12). The 95% prediction interval for this response heterogeneity SD was wide (−10.20 to 14.57 units /100). The control group-adjusted proportion of “responders” in the population who would be estimated to exceed a clinically important change of 10/100 ranged from 18 to 45%. Therefore, when baseline-to-follow up random variability in disability is taken into account (informed by the control arm), there is currently insufficient evidence for the notion of clinically important inter-individual differences in disability responses to PNE in people with chronic musculoskeletal pain. The protocol was published on PROSPERO (CRD42017068436). Perspective: We bring a novel method to pain science for calculating inter-individual differences in response to a treatment. This is conductedwithin the context of a systematic review and meta-analysis on PNE. We highlight how using erroneous methods for calculating inter-individual differences can drastically change conclusions when compared to appropriate methods.
| Item Type: | Article |
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| Uncontrolled Keywords: | Science & Technology; Life Sciences & Biomedicine; Clinical Neurology; Neurosciences; Neurosciences & Neurology; Pain; neuroscience; education; Individual response variance; LOW-BACK-PAIN; NEUROPHYSIOLOGY EDUCATION; EXERCISE; PEOPLE; FIBROMYALGIA; EXPLORATION; EXPERIENCES; Humans; Individuality; Neurosciences; Patient Education as Topic; Randomized Controlled Trials as Topic; Pain Management; Musculoskeletal Pain; Chronic Pain; Outcome Assessment, Health Care; Individual response variance; Pain; education; neuroscience; Chronic Pain; Humans; Individuality; Musculoskeletal Pain; Neurosciences; Outcome Assessment, Health Care; Pain Management; Patient Education as Topic; Randomized Controlled Trials as Topic; 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences; Anesthesiology |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Elsevier |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 20 May 2022 12:06 |
| Last Modified: | 20 May 2022 12:15 |
| DOI or ID number: | 10.1016/j.jpain.2020.03.006 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16896 |
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