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Zahedipour, F, Hosseini, S, Henney, NC, Barreto, G and Sahebkar, A (2022) Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases. Neural Regeneration Research, 17 (8). pp. 1675-1684. ISSN 1673-5374
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Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases.pdf - Published Version Available under License Creative Commons Attribution Non-commercial Share Alike. Download (618kB) | Preview |
Abstract
Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders. Tumor necrosis factor alpha has been reported to play a major role in the central nervous system in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and many other neurodegenerative diseases. Therefore, a potent proinflammatory/proapoptotic tumor necrosis factor alpha could be a strong candidate for targeted therapy. Plant derivatives have now become promising candidates as therapeutic agents because of their antioxidant and chemical characteristics, and anti-inflammatory features. Recently, phytochemicals including flavonoids, terpenoids, alkaloids, and lignans have generated interest as tumor necrosis factor alpha inhibitor candidates for a number of diseases involving inflammation within the nervous system. In this review, we discuss how phytochemicals as tumor necrosis factor alpha inhibitors are a therapeutic strategy targeting neurodegeneration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1109 Neurosciences |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Medknow |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 25 May 2022 09:22 |
| Last Modified: | 25 May 2022 09:30 |
| DOI or ID number: | 10.4103/1673-5374.332128 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16930 |
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