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A comparison of modelled serum cTnT and cTnI kinetics after 60 min swimming

Cirer-Sastre, R, Jiménez-Gaytán, R, Carranza-García, LE, George, K, Apple, FS, Navarro-Orocio, R, López-García, R, Reverter-Masía, J, Mayolas-Pi, C, Morales-Corral, PG and Legaz-Arrese, A (2022) A comparison of modelled serum cTnT and cTnI kinetics after 60 min swimming. BIOMARKERS. ISSN 1354-750X

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Post-exercise elevations of cardiac troponin T (cTnT) and I (cTnI) are often used in isolation but interpreted interchangeably. Research suggests, however, that post-exercise cTn kinetic might differ with each isoform. In this cross-sectional observational study, we collected blood samples before, immediately after (5 minutes), and at 1-, 3-, 6-, 12-, and 24-hours post-exercise in a mixed cohort of 56 participants after a 60-min (age range from 14 to 22, 57.1% female). swimming trial. Cardiac troponin kinetics were modeled using Bayesian mixed-effects models to estimate time to peak (TTP) and peak concentration (PC) for each isoform, while controlling for participants sex, tanner stage and average relative heart rate during the test. Exercise induced an elevation of cTnT and cTnI in 93% and 75% of the participants, respectively. Cardiac troponin T peaked earlier, at 2.9 h (CI: 2.6 - 3.2 h) post-exercise, whereas cTnI peaked later, at 4.5 h (CI: 4.2 - 4.9 h). Peak concentrations for cTnT and cTnI were 2.5 ng/L, CI: 0 - 11.2 ng/L and 2.16 ng/L, CI: 0 - 22.7 ng/L, respectively. Additionally, we did not observe a systematic effect of sex and maturational status mediating cTn responses.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in BIOMARKERS on 23/6/22, available at: http://www.tandfonline.com/10.1080/1354750X.2022.2080272
Uncontrolled Keywords: Sports science/exercise; cardiac biomarkers; exercise; heart damage; hs-cTnI; hs-cTnT; 1002 Environmental Biotechnology; Toxicology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA0440 Study and Teaching. Research
Divisions: Sport & Exercise Sciences
Vice-Chancellor's Office
Publisher: Taylor & Francis
SWORD Depositor: A Symplectic
Date Deposited: 31 May 2022 10:12
Last Modified: 23 Jun 2023 00:50
DOI or ID number: 10.1080/1354750X.2022.2080272
URI: https://researchonline.ljmu.ac.uk/id/eprint/16982
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