Danquah, CA, Minkah, PAB, Agana, TA, Moyo, P, Ofori, M, Doe, P, Rali, S, Osei Duah Junior, I, Amankwah, KB, Somuah, SO, Nugbemado, IN, Maharaj, VJ, Bhakta, S and Gibbons, S (2022) The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae. Molecules (Basel, Switzerland), 27 (14). ISSN 1420-3049

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Abstract

Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antioxidant, antimicrobial, and immunomodulatory effects. Traditionally, natural products from Amaryllidaceae are utilized to treat non-communicable and infectious human diseases. Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer’s disease, which underscores the importance of the Amaryllidaceae alkaloids. Although Amaryllidaceae provide a plethora of biologically active compounds, there is tardiness in their development into clinically pliable medicines. Other genera, including Cyrtanthus and Tulbaghia, have received little attention as potential sources of promising drug candidates. Given the reciprocal relationship of the increasing burden of human diseases and limited availability of medicinal therapies, more rapid drug discovery and development are desirable. To expedite clinically relevant drug development, we present here evidence on bioactive compounds from the genera Allium, Tulgbaghia, Cyrtanthus and Crinum and describe their traditional and pharmacological applications.

Item Type:	Article
Uncontrolled Keywords:	Humans; Allium; Crinum; Amaryllidaceae Alkaloids; Plant Extracts; Phytochemicals; Amaryllidaceae; Allium; Amaryllidaceae; Crinum; Cyrtanthus; Tulbaghia; alkaloids; drug discovery; natural products; pharmacological activity; phytochemicals; Allium; Amaryllidaceae; Amaryllidaceae Alkaloids; Crinum; Humans; Phytochemicals; Plant Extracts; 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; 0307 Theoretical and Computational Chemistry; Organic Chemistry
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	MDPI AG
SWORD Depositor:	A Symplectic
Date Deposited:	04 Aug 2022 08:43
Last Modified:	04 Aug 2022 08:45
DOI or ID number:	10.3390/molecules27144475
URI:	https://researchonline.ljmu.ac.uk/id/eprint/17330

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