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Vermeulen, JJM, Meijer, M, de Vries, FBG, Reijnen, MMPJ, Holewijn, S and Thijssen, DHJ (2022) A systematic review summarizing local vascular characteristics of the aneurysm wall to predict progression and rupture risk of abdominal aortic aneurysms. Journal of vascular surgery. ISSN 0741-5214
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A systematic review summarizing local vascular characteristics of the aneurysm.pdf - Accepted Version Available under License Creative Commons Attribution. Download (442kB) | Preview |
Abstract
Objective: Rupture risk prediction of abdominal aortic aneurysms (AAA), and hence clinical decision making on the need for surgery, is currently based on AAA diameter and growth rate. Unfortunately, these measures provide limited predictive information. This study summarized measures of local vascular characteristics of the aneurysm wall that, independent of AAA size, could predict AAA progression and AAA rupture.
Method: Pubmed and Web of Science were systematically searched up to September 13th, 2021 to identify relevant articles investigating the relationship between local vascular characteristics of the aneurysm wall and AAA growth or rupture in humans. Quality assessment was performed with the ROBINS-I tool. All included articles were divided in four types of measure of arterial wall characteristics; metabolism, calcification, intraluminal thrombus and compliance.
Results: Twenty articles were included. Metabolism of the aneurysm wall, especially measured with ultra-small superparamagnetic iron oxide uptake, and calcification were significantly related to AAA growth. Higher intraluminal thrombus volume and thickness was in one study positively correlated to AAA growth and in another study negatively correlated. AAA compliance demonstrated no correlation with AAA growth and rupture. Aneurysmal wall characteristics showed no association with AAA rupture. However, metabolism measured by ultra-small superparamagnetic iron oxide uptake, but none of the other measures, showed a trend toward a relation to AAA rupture, although not statistically significant.
Conclusion: Current measures of aortic wall characteristics have potential to predict AAA growth, especially measuring metabolism and calcification. Evidence regarding AAA rupture is scarce and although more work is needed, aortic wall metabolism could potentially be related to AAA rupture. This highlights the role of aortic wall characteristics in the progression of AAA, but also the potential to improve prediction of AAA growth and rupture.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Abdominal aortic aneurysm; aortic wall; growth; rupture; Cardiovascular System & Hematology; 11 Medical and Health Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Elsevier BV |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 09 Aug 2022 09:12 |
| Last Modified: | 09 Aug 2022 09:15 |
| DOI or ID number: | 10.1016/j.jvs.2022.07.008 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/17356 |
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