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Chaudhry, T, Coxon, CR and Ross, K (2022) Trading places: Peptide and small molecule alternatives to oligonucleotide-based modulation of microRNA expression. Drug Discovery Today, 27 (11). ISSN 1359-6446
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Trading places Peptide and small molecule alternatives to oligonucleotide-based modulation of microRNA expression.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
It is well established that microRNA (miRNA) dysregulation is involved in the development and progression of various diseases, especially cancer. Emerging evidence suggests that small molecule and peptide agents can interfere with miRNA disease pathways. Despite this, very little is known about structural features that drive drug–miRNA interactions and subsequent inhibition. In this review, we highlight the advances made in the development of small molecule and peptide inhibitors of miRNA processing. Specifically, we attempt to draw attention to peptide features that may be critical for interaction with the miRNA secondary structure to regulate miRNA expression. We hope that this review will help to establish peptides as exciting miRNA expression modulators and will contribute towards the development of the first miRNA-targeting peptide therapy.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0601 Biochemistry and Cell Biology; 1115 Pharmacology and Pharmaceutical Sciences; Medicinal & Biomolecular Chemistry |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Elsevier BV |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 05 Sep 2022 08:58 |
| Last Modified: | 22 Sep 2022 10:00 |
| DOI or ID number: | 10.1016/j.drudis.2022.08.005 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/17479 |
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