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Sedentary behaviour and brain health in middle-aged and older adults: A systematic review

Maasakkers, CM, Weijs, RWJ, Dekkers, C, Gardiner, PA, Ottens, R, Olde Rikkert, MGM, Melis, RJF, Thijssen, DHJ and Claassen, JAHR (2022) Sedentary behaviour and brain health in middle-aged and older adults: A systematic review. Neuroscience and Biobehavioral Reviews, 140. ISSN 0149-7634

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Open Access URL: https://doi.org/10.1016/j.neubiorev.2022.104802 (Published version)


Sedentary behaviour may increase the risk of dementia. Studying physiological effects of sedentary behaviour on cerebral health may provide new insights into the nature of this association. Accordingly, we reviewed if and how acute and habitual sedentary behaviour relate to brain health factors in middle-aged and older adults (≥45 years). Four databases were searched. Twenty-nine studies were included, with mainly cross-sectional designs. Nine studies examined neurotrophic factors and six studied functional brain measures, with the majority of these studies finding no associations with sedentary behaviour. The results from studies on sedentary behaviour and cerebrovascular measures were inconclusive. There was a tentative association between habitual sedentary behaviour and structural white matter health. An explanatory pathway for this effect might relate to the immediate vascular effects of sitting, such as elevation of blood pressure. Nevertheless, due to the foremost cross-sectional nature of the available evidence, reverse causality could also be a possible explanation. More prospective studies are needed to understand the potential of sedentary behaviour as a target for brain health.

Item Type: Article
Uncontrolled Keywords: Brain; Humans; Cross-Sectional Studies; Aged; Middle Aged; Sedentary Behavior; Brain health; Dementia; Neurodegeneration; Sedentary behaviour; Sitting; Aged; Brain; Cross-Sectional Studies; Humans; Middle Aged; Sedentary Behavior; 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences; Behavioral Science & Comparative Psychology
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Sport & Exercise Sciences
Publisher: Elsevier BV
SWORD Depositor: A Symplectic
Date Deposited: 16 Sep 2022 09:58
Last Modified: 16 Sep 2022 10:00
DOI or ID number: 10.1016/j.neubiorev.2022.104802
URI: https://researchonline.ljmu.ac.uk/id/eprint/17592
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