Braga, GÚL, Silva-Junior, GJ, Brancini, GTP, Hallsworth, JE and Wainwright, M (2022) Photoantimicrobials in agriculture. Journal of photochemistry and photobiology. B, Biology, 235. p. 112548. ISSN 1011-1344

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Abstract

Classical approaches for controlling plant pathogens may be impaired by the development of pathogen resistance to chemical pesticides and by limited availability of effective antimicrobial agents. Recent increases in consumer awareness of and/or legislation regarding environmental and human health, and the urgent need to improve food security, are driving increased demand for safer antimicrobial strategies. Therefore, there is a need for a step change in the approaches used for controlling pre- and post-harvest diseases and foodborne human pathogens. The use of light-activated antimicrobial substances for the so-called antimicrobial photodynamic treatment is known to be effective not only in a clinical context, but also for use in agriculture to control plant-pathogenic fungi and bacteria, and to eliminate foodborne human pathogens from seeds, sprouted seeds, fruits, and vegetables. Here, we take a holistic approach to review and re-evaluate recent findings on: (i) the ecology of naturally-occurring photoantimicrobials, (ii) photodynamic processes including the light-activated antimicrobial activities of some plant metabolites, and (iii) fungus-induced photosensitization of plants. The inhibitory mechanisms of both natural and synthetic light-activated substances, known as photosensitizers, are discussed in the contexts of microbial stress biology and agricultural biotechnology. Their modes-of-antimicrobial action make them neither stressors nor toxins/toxicants (with specific modes of poisonous activity), but a hybrid/combination of both. We highlight the use of photoantimicrobials for the control of plant-pathogenic fungi and quantify their potential contribution to global food security.

Item Type:	Article
Uncontrolled Keywords:	Antimicrobial photodynamic treatment (APDT); Cellular toxicity versus stress; Foodborne pathogens; Global food security; Photoantimicrobials; Plant-pathogenic fungi; 0299 Other Physical Sciences; 0601 Biochemistry and Cell Biology; Biophysics
Subjects:	T Technology > TX Home economics > TX341 Nutrition. Foods and food supply Q Science > QH Natural history > QH301 Biology R Medicine > RS Pharmacy and materia medica S Agriculture > S Agriculture (General)
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Elsevier
SWORD Depositor:	A Symplectic
Date Deposited:	26 Sep 2022 10:40
Last Modified:	05 Sep 2023 00:50
DOI or ID number:	10.1016/j.jphotobiol.2022.112548
URI:	https://researchonline.ljmu.ac.uk/id/eprint/17668

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