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Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer

Preethi, KA, Selvakumar, S, Ross, K, Jayaraman, S, Tusubira, D and Sekar, D (2022) Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer. Molecular Cancer, 21 (1).

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Open Access URL: https://molecular-cancer.biomedcentral.com/article... (Published version)


Detecting cancer at an early stage before clinical manifestation could be an effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers with high efficacy could be a promising approach for non-invasive diagnosis of cancer.

Main text
Liquid biopsies are increasingly used as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation. Many bodily fluids contain exosomal microRNAs (miRNAs) which could provide a new class of biomarkers for early and minimally invasive cancer diagnosis due to the stability of miRNAs in exosomes. In this review, we mainly focused on the exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers.

Exosomal miRNAs can be used as diagnostic and prognosis biomarkers that provide unique insights and a more dynamic perspective of the progression and therapeutic responses in various malignancies. Therefore, the development of novel and more sensitive technologies that exploit exosomal miRNAs should be a priority for cancer management.

Item Type: Article
Uncontrolled Keywords: Oncology & Carcinogenesis; 1112 Oncology and Carcinogenesis
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer Science and Business Media LLC
SWORD Depositor: A Symplectic
Date Deposited: 03 Oct 2022 11:59
Last Modified: 03 Oct 2022 11:59
DOI or ID number: 10.1186/s12943-022-01525-9
URI: https://researchonline.ljmu.ac.uk/id/eprint/17704
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