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Genetic profile of sports climbing athletes from three different ethnicities

Saito, M, Ginszt, M, Semenova, EA, Massidda, M, Huminska-Lisowska, K, Michałowska-Sawczyn, M, Homma, H, Cięszczyk, P, Okamoto, T, Larin, AK, Generozov, EV, Majcher, P, Nakazato, K, Ahmetov, II and Kikuchi, N (2021) Genetic profile of sports climbing athletes from three different ethnicities. Biology of Sport, 39 (4). pp. 913-919. ISSN 0860-021X

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Open Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC95363... (Published version)


This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552 genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russian: n = 184). Genotyping results were analyzed using the TaqMan approach in Japanese and Polish subjects and HumanOmni1-Quad Bead Chips in Russian subjects. There were no significant differences in ACTN3 R577X and ACE I/D polymorphism distribution between climbers and controls in any ethnic cohort or model. The frequencies of the C allele in the CKM polymorphism and the T allele in the TRHR polymorphism were higher in climbers than in controls only in the Russian cohort (p = 0.045 and p = 0.039, respectively). The results of the meta-analysis on three cohorts showed that the frequency of XX + RX genotypes in the ACTN3 R577X polymorphism was significantly higher in climbers than that in the controls (p = 0.01). The X allele of the ACTN3 R577X polymorphism was associated with sport climbing status, as assessed using a meta-analysis of climbers across three different ethnicities.

Item Type: Article
Uncontrolled Keywords: Sport Sciences; 1106 Human Movement and Sports Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Termedia Publishing
SWORD Depositor: A Symplectic
Date Deposited: 11 Nov 2022 12:56
Last Modified: 28 Mar 2023 15:38
DOI or ID number: 10.5114/biolsport.2022.109958
URI: https://researchonline.ljmu.ac.uk/id/eprint/18100
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