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Alqathama, A, Yonbawi, AR, Shao, L, Bader, A, Abdalla, AN, Gibbons, S and Prieto, JM (2022) The in vitro cytotoxicity against human melanoma cells, tyrosinase inhibition and antioxidant activity of Grewia tenax leaves extracts. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 22 (2). pp. 268-276.
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Abstract
Grewia tenax (Forssk.) Fiori (Malvaceae) grows in the Arabian Peninsula and is used for several medicinal purposes. To characterize the dermatological bioactivities of G. tenax in terms of its antimelanoma, antityrosinase and antioxidant activities. Cytotoxicity was assessed by cell proliferation and mitochondrial viability assays. Ability to inhibit mushroom tyrosinase and scavenge free radicals were evaluated by an enzymatic and DPPH scavenging microtiter assay, respectively. Phytochemical analyses were carried out using TLC, HPLC-UV and NMR. The chloroform extract shown significant cytotoxic activity in terms of mitochondrial viability (43 ± 14 µg/mL). We identified lupeol and b-sitosterol as the main active components for the tyrosinase inhibitory activity of the hexane extract. Scavenging activity of the DPPH· radical was confined to the water extract. Extracts from this plant have the potential to be used as a base in the development of cosmeceutical products intended to whiten skin or to combat radical-induced physiopathological processes.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | MS-Editions |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 08 Dec 2022 13:11 |
| Last Modified: | 03 Jan 2023 13:15 |
| DOI or ID number: | 10.37360/blacpma.23.22.2.20 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18338 |
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