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Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent

Nahar, L, Al Groshi, A, Kumar, A and Sarker, S (2022) Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent. Molecules, 27. ISSN 1420-3049

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Open Access URL: https://doi.org/10.3390/molecules27248786 (Published)


Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e.g., antioxidant, antimicrobial and anti-inflammatory, as well as anticancer potential. This review presents, for the first time, a comprehensive overview of the distribution of arbutin in the plant kingdom and critically appraises its therapeutic potential as an anticancer agent based on the literature published until the end of August 2022, accessed via several databases, e.g., Web of Science, Science Direct, Dictionary of Natural Products, PubMed and Google Scholar. The keywords used in the search were arbutin, cancer, anticancer, distribution and hydroquinone. Published outputs suggest that arbutin has potential anticancer properties against bladder, bone, brain, breast, cervix, colon, liver, prostate and skin cancers and a low level of acute or chronic toxicity.

Item Type: Article
Uncontrolled Keywords: 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; 0307 Theoretical and Computational Chemistry; Organic Chemistry
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
SWORD Depositor: A Symplectic
Date Deposited: 13 Dec 2022 12:25
Last Modified: 13 Dec 2022 12:25
DOI or ID number: doi.org/10.3390/molecules27248786
URI: https://researchonline.ljmu.ac.uk/id/eprint/18384
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